Reproduction Abstracts

Chromatin remodeling factor chromodomain helicase DNA binding protein 1 (CHD1) is a protein belonging to the family of ATPase dependent chromatin remodeling factors and recognizes tri-methylated lysine 4 of histone H3 (H3K4me3) in chromatin. Histone methylation is one of the epigenetic modifications involved in gene regulation and H3K4me3 is associated with a transcriptionally permissive state of chromatin. It has been shown that CHD1 facilitates pre-mRNA splicing, and is requ...

Pluripotent stem cells (PSCs) in large domestic animals including cattle are expected to be used as means for genetic improvement and production of disease-model animals. There are two types of PSCs: naive and primed. Ontogenetically, naive PSCs correspond to an earlier developmental state compared to other types of PSCs and have the capacity for producing chimeric offspring. Previously reported PSCs in large domestic animals are classified as primed type. In this study, putat...